Arterial stiffness and multiple organ damage: a longitudinal study in population.

ABSTRACT:

Aims

Previous cross-sectional observation identified arterial aging, indexed as pulse-wave velocity (PWV), as a key determinant of the simultaneous multiple organ damage (heart, carotid artery, and kidney). The aim of the present cohort study is to investigate trajectories of repeated measures of PWV and traditional CV risk factors in subjects who eventually presented clinical evidence of multiple organ damage in the SardiNIA study.

Methods and results

Organ damage was measured in the heart (left ventricular hypertrophy, LVH), the common carotid artery (intima-media thickness > 0.9 mm and/or plaque), and the kidney (eGFR < 60 ml/min/1.73 m²) of 2130 men and women of a broad age range participating the SardiNIA study. SHATS was defined as the simultaneous occurrenc

SUBMITTER: Scuteri A 

PROVIDER: S-EPMC8476312 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature