Proto-oncogene Pokemon in thyroid cancer: a potential promoter of tumorigenesis in papillary thyroid carcinoma.

ABSTRACT:

Background

Pokemon is an oncogenic transcription regulator that plays a critical role in cellular differentiation. Although it has been found to be overexpressed in several types of cancer involving different organs, its role in thyroid gland has yet to be reported. The objective of this study was to evaluate the expression of Pokemon in papillary thyroid carcinoma (PTC) based on clinicopathological parameters.

Methods

Tissue microarray samples derived from patients with PTC or benign thyroid disease were used to evaluate Pokemon expression based on immunohistochemical analysis. Correlations of its expression with various clinicopathological parameters were then analyzed.

Results

Pokemon expression was observed in 22.0% of thyroid follicular cells from the normal grou

SUBMITTER: Chang K 

PROVIDER: S-EPMC8476314 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature