External validation of the Toronto hepatocellular carcinoma risk index in a Swedish population.

ABSTRACT:

Background & aims

The Toronto hepatocellular carcinoma (HCC) risk index (THRI) is a predictive model to determine the risk of HCC in patients with cirrhosis. This study aimed to externally validate the THRI in a Swedish setting to investigate whether it could identify patients not requiring HCC surveillance.

Methods

From 2004-2017, 2,491 patients with cirrhosis at the Karolinska University Hospital were evaluated. Patients were classified into low-, intermediate- and high-risk groups for future HCC according to the THRI. Harrell's C-index, calibration-in-the-large, calibration slope and goodness-of-fit estimates were calculated to assess model discrimination and calibration. Cox proportional hazards regression was used to determine the risk of HCC.

Results

Most patien

SUBMITTER: Astrom H 

PROVIDER: S-EPMC8476346 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature