Insights into homeobox B9: a propeller for metastasis in dormant prostate cancer progenitor cells.

ABSTRACT:

Background

Metastasis is the major cause of treatment failure and cancer-related deaths in prostate cancer (PCa) patients. Our previous study demonstrated that a CD44⁺ subpopulation isolated from PCa cells or tumours possesses both stem cell properties and metastatic potential, serving as metastatic prostate cancer stem cells (mPCSCs) in PCa metastasis. However, the underlying mechanisms remain unknown.

Methods

In this study, we established PCa models via the orthotopic and subcutaneous implantation of different human PCa cancer cell lines, and compared the metastatic efficacy, after which process function analysis of target genes was pinpointed.

Results

Several novel differentially expressed genes (DEGs) between orthotopic and ectopic tumours were identifi

SUBMITTER: Sui Y 

PROVIDER: S-EPMC8476533 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature