In vitro and in vivo comparative study of a novel ⁶⁸Ga-labeled PSMA-targeted inhibitor and ⁶⁸Ga-PSMA-11.

ABSTRACT: ⁶⁸Ga-radiolabeled small molecules that specifically target prostate-specific membrane antigen (PSMA) have been extensively investigated, and some of these tracers have been used in the diagnosis of prostate cancer via ⁶⁸Ga-positron emission tomography (⁶⁸Ga-PET). Nevertheless, current ⁶⁸Ga-labeled radiotracers show only fair detection rates for metastatic prostate cancer lesions, especially those with lower levels of prostate specific antigen (PSA), which often occurs in the biochemical recurrence of prostate cancer. The goal of this study was to design and synthesize a new PSMA-targeted radiotracer, ⁶⁸Ga-SC691, with high affinity for prostate cancer cells and excellent pharmacokinetics. To this end, structural optimization was carried

SUBMITTER: Chen H 

PROVIDER: S-EPMC8476564 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature