Electromagnetic stimulation increases mitochondrial function in osteogenic cells and promotes bone fracture repair.

ABSTRACT: Bone fracture is a growing public health burden and there is a clinical need for non-invasive therapies to aid in the fracture healing process. Previous studies have demonstrated the utility of electromagnetic (EM) fields in promoting bone repair; however, its underlying mechanism of action is unclear. Interestingly, there is a growing body of literature describing positive effects of an EM field on mitochondria. In our own work, we have previously demonstrated that differentiation of osteoprogenitors into osteoblasts involves activation of mitochondrial oxidative phosphorylation (OxPhos). Therefore, it was reasonable to propose that EM field therapy exerts bone anabolic effects via stimulation of mitochondrial OxPhos. In this study, we show that application of a low intensity constant EM

SUBMITTER: Hollenberg AM 

PROVIDER: S-EPMC8476611 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature