Ontology highlight
ABSTRACT:
SUBMITTER: Lang M
PROVIDER: S-EPMC8476650 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
iScience 20210914 10
Indole is a molecule proposed to be involved in bacterial signaling. We find that indole secretion is induced by sublethal tobramycin concentrations and increases persistence to aminoglycosides in <i>V. cholerae</i>. Indole transcriptomics showed increased expression of <i>raiA</i>, a ribosome associated factor. Deletion of <i>raiA</i> abolishes the appearance of indole dependent persisters to aminoglycosides, although its overexpression leads to 100-fold increase of persisters, and a reduction ...[more]