Heme Oxygenase-1 at the Nexus of Endothelial Cell Fate Decision Under Oxidative Stress.

ABSTRACT: Endothelial cells (ECs) form the inner lining of blood vessels and are central to sensing chemical perturbations that can lead to oxidative stress. The degree of stress is correlated with divergent phenotypes such as quiescence, cell death, or senescence. Each possible cell fate is relevant for a different aspect of endothelial function, and hence, the regulation of cell fate decisions is critically important in maintaining vascular health. This study examined the oxidative stress response (OSR) in human ECs at the boundary of cell survival and death through longitudinal measurements, including cellular, gene expression, and perturbation measurements. 0.5 mM hydrogen peroxide (HP) produced significant oxidative stress, placed the cell at this junction, and provided a model to study the eff

SUBMITTER: Raghunandan S 

PROVIDER: S-EPMC8476872 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature