Ontology highlight
ABSTRACT:
SUBMITTER: Gingrich AA
PROVIDER: S-EPMC8476892 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Gingrich Alicia A AA Reiter Taylor E TE Judge Sean J SJ York Daniel D Yanagisawa Mio M Razmara Aryana A Sturgill Ian I Basmaci Ugur Nur UN Brady Rachel V RV Stoffel Kevin K Murphy William J WJ Rebhun Robert B RB Brown C Titus CT Canter Robert J RJ
Frontiers in immunology 20210914
Natural killer (NK) cells are key effectors of the innate immune system, but major differences between human and murine NK cells have impeded translation. Outbred dogs offer an important link for studies of NK biology and immunotherapy. We analyzed gene expression of putative NK populations from healthy dogs and dogs with naturally-occurring cancers examining differential gene expression across multiple conditions, including steady-state, <i>in vitro</i> activation with cytokines and co-culture, ...[more]