Getting to know each other: PPIMem, a novel approach for predicting transmembrane protein-protein complexes.

ABSTRACT: Because of their considerable number and diversity, membrane proteins and their macromolecular complexes represent the functional units of cells. Their quaternary structure may be stabilized by interactions between the α-helices of different proteins in the hydrophobic region of the cell membrane. Membrane proteins equally represent potential pharmacological targets par excellence for various diseases. Unfortunately, their experimental 3D structure and that of their complexes with other intramembrane protein partners are scarce due to technical difficulties. To overcome this key problem, we devised PPIMem, a computational approach for the specific prediction of higher-order structures of α-helical transmembrane proteins. The novel approach involves proper identification of the amino acid r

SUBMITTER: Khazen G 

PROVIDER: S-EPMC8476896 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature