Four plasma miRNAs act as biomarkers for diagnosis and prognosis of non-small cell lung cancer.

ABSTRACT: Previous studies have reported that the aberrant expression of circulating microRNAs (miRNAs/miRs) can be used as diagnostic and prognostic markers in non-small cell lung cancer (NSCLC). The present study aimed to assess the diagnostic and prognostic predictive values of four plasma miRNAs for NSCLC. A total of 12 candidate miRNAs were selected that have previously been reported to be aberrantly expressed in NSCLC, and their plasma levels in the training set were detected via reverse transcription-quantitative PCR analysis. The screened out miRNAs were further validated in the testing set. The area under the curve (AUC) of the receiver operating characteristic curve was constructed to evaluate diagnostic performance. Kaplan-Meier survival analysis was performed to assess the association be

SUBMITTER: Jiang HG 

PROVIDER: S-EPMC8477070 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature