Circulatory 25(OH)D and 1,25(OH)₂D as differential biomarkers between multiple system atrophy and Parkinson's disease patients.

ABSTRACT:

Background and purpose

There is sufficient evidence to support vitamin D's noncalcemic effects and the role of vitamin D deficiency in the development of a wide range of neurological disorders. This study aimed to evaluate whether serum 25(OH)D and 1,25(OH) 2 D could be used as biomarkers to differentiate between healthy subjects (HS), multiple system atrophy (MSA) and Parkinson's disease (PD) patients of both genders.

Methods

A total of 107 subjects were included in this study, divided into three groups: 1- HS (n = 61), 2- MSA patients (n = 19), and 3- PD patients (n = 27). The patients were assessed using UMSARS II, UPDRS III, H&Y, MMSE and MoCA rating scales. The levels of 25(OH)D and 1,25(OH) 2 D in serum were determined using the radioimmunoassay te

SUBMITTER: Ogura H 

PROVIDER: S-EPMC8477135 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature