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Pathogenesis and treatment of multiple myeloma bone disease.

ABSTRACT: Multiple myeloma (Plasma cell myeloma), a malignancy of the plasma cells, exhibits tumor expansion preferentially in the bone marrow and the development of bone-destructive lesions. Multiple myeloma is still an incurable disease with changes in the bone marrow microenvironment in favor of the survival and proliferation of multiple myeloma cells and bone destruction. In this review, we described the recent findings on the regulators involved in the development of myeloma bone diseases, and succinctly summarize currently available therapeutic options and the development of novel bone modifying agents for myeloma treatment.

SUBMITTER: Hiasa M 

PROVIDER: S-EPMC8477206 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Pathogenesis and treatment of multiple myeloma bone disease.

Hiasa Masahiro M   Harada Takeshi T   Tanaka Eiji E   Abe Masahiro M  

The Japanese dental science review 20210923

Multiple myeloma (Plasma cell myeloma), a malignancy of the plasma cells, exhibits tumor expansion preferentially in the bone marrow and the development of bone-destructive lesions. Multiple myeloma is still an incurable disease with changes in the bone marrow microenvironment in favor of the survival and proliferation of multiple myeloma cells and bone destruction. In this review, we described the recent findings on the regulators involved in the development of myeloma bone diseases, and succin  ...[more]

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