No evidence of neuronal damage as measured by neurofilament light chain in a HIV cure study utilising a kick-and-kill approach.

ABSTRACT:

Objective

HIV-remission strategies including kick-and-kill could induce viral transcription and immune-activation in the central nervous system, potentially causing neuronal injury. We investigated the impact of kick-and-kill on plasma neurofilament light (NfL), a marker of neuro-axonal injury, in RIVER trial participants commencing antiretroviral treatment (ART) during primary infection and randomly allocated to ART-alone or kick-and-kill (ART + vaccination + vorinostat (ART + V + V)).

Design

Sub-study measuring serial plasma NfL concentrations.

Methods

Plasma NfL (using Simoa digital immunoassay), plasma HIV-1 RNA (using single-copy assay) and total HIV-1 DNA (using quantitative polymerase chain reaction in peripheral CD4⁺ T-cells) were measured at random

SUBMITTER: Alagaratnam J 

PROVIDER: S-EPMC8477217 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature