Long-term Outcomes of Transcatheter Arterial Chemoembolization Combined With Radiofrequency Ablation as an Initial Treatment for Early-Stage Hepatocellular Carcinoma.

ABSTRACT:

Importance

The long-term outcomes of transcatheter arterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) are not determined.

Objective

To report the long-term outcomes of TACE-RFA.

Design, setting, and participants

This cohort study analyzed long-term follow-up data from a phase 3 randomized clinical trial of adults with early HCC conducted from October 2006 to June 2009. Participants were randomly assigned to the TACE-RFA group or the RFA group in a 1:1 ratio and followed up approximately 6 years after the trial was closed. Data analysis was performed March 2020.

Exposure

In the TACE-RFA group, TACE was performed first, and RFA was done 2 weeks later.

Main outcomes and measures

Overall survival (OS) and recurrence-free survival (

SUBMITTER: Zhang YJ 

PROVIDER: S-EPMC8477266 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature