Serum phosphate and chronic kidney and cardiovascular disease: Phosphorus potential implications in general population.

ABSTRACT: It has already been established that in end-stage renal disease, hyperphosphatemia causes soft tissue calcification including vascular calcifications. It has also been supported that there is a connection between increased serum phosphate and morbidity in subjects, who suffer from renal disease. However, studies in these populations conferred mixed results. Several warnings are included in the role of serum phosphorus on cardiovascular disease in normal populations. Homeostasis of serum phosphate is obtained by the cooperation between regulatory hormones, cellular receptors and bone metabolic factors. There is the probability that one or more phosphate regulatory factors, rather than phosphate directly, may be responsible for observed associations with calcification and cardiovascular even

SUBMITTER: Raikou VD 

PROVIDER: S-EPMC8477270 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature