Genomic characterization of Achromobacter species isolates from chronic and occasional lung infection in cystic fibrosis patients.

ABSTRACT: Achromobacter species are increasingly being detected in cystic fibrosis (CF) patients, where they can establish chronic infections by adapting to the lower airway environment. To better understand the mechanisms contributing to a successful colonization by Achromobacter species, we sequenced the whole genome of 54 isolates from 26 patients with occasional and early/late chronic lung infection. We performed a phylogenetic analysis and compared virulence and resistance genes, genetic variants and mutations, and hypermutability mechanisms between chronic and occasional isolates. We identified five Achromobacter species as well as two non-affiliated genogroups (NGs). Among them were the frequently isolated Achromobacter xylosoxidans and four other species whose cli

SUBMITTER: Veschetti L 

PROVIDER: S-EPMC8477391 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature