A global transcriptomic analysis of Staphylococcus aureus biofilm formation across diverse clonal lineages.

ABSTRACT: A key characteristic of Staphylococcus aureus infections, and one that also varies phenotypically between clones, is that of biofilm formation, which aids in bacterial persistence through increased adherence and immune evasion. Though there is a general understanding of the process of biofilm formation - adhesion, proliferation, maturation and dispersal - the tightly orchestrated molecular events behind each stage, and what drives variation between S. aureus strains, has yet to be unravelled. Herein we measure biofilm progression and dispersal in real-time across the five major S. aureus CDC-types (USA100-USA500) revealing adherence patterns that differ markedly amongst strains. To gain insight into this, we performed transcriptomic profiling on these isolates at multi

SUBMITTER: Tomlinson BR 

PROVIDER: S-EPMC8477394 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature