Comparative genomic analysis of <i>Escherichia coli</i> isolates from cases of bovine clinical mastitis identifies nine specific pathotype marker genes.

ABSTRACT: Escherichia coli is a major causative agent of environmental bovine mastitis and this disease causes significant economic losses for the dairy industry. There is still debate in the literature as to whether mammary pathogenic E. coli (MPEC) is indeed a unique E. coli pathotype, or whether this infection is merely an opportunistic infection caused by any E. coli isolate being displaced from the bovine gastrointestinal tract to the environment and, then, into the udder. In this study, we conducted a thorough genomic analysis of 113 novel MPEC isolates from clinical mastitis cases and 100 bovine commensal E. coli isolates. A phylogenomic analysis indicated that MPEC and commensal E. coli isolates formed clades based on common sequence types and O anti

SUBMITTER: Jung D 

PROVIDER: S-EPMC8477405 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature