NMR studies of group 8 metallodrugs: ¹⁸⁷Os-enriched organo-osmium half-sandwich anticancer complex.

ABSTRACT: We report the synthesis of the organo-osmium anticancer complex [Os(η⁶-p-cym)(N,N-azpy-NMe₂)Br]PF₆ (1) containing natural abundance ¹⁸⁷Os (1.96%), and isotopically-enriched (98%) [¹⁸⁷Os]-1. Complex 1 and [¹⁸⁷Os]-1 contain a π-bonded para-cymene (p-cym), a chelated 4-(2-pyridylazo)-N,N-dimethylaniline (azpy-NMe₂), and a monodentate bromide as ligands. The X-ray crystal structure of 1 confirmed its half-sandwich 'piano-stool' configuration. Complex 1 is a member of a family of potent anticancer complexes, and exhibits sub-micromolar activity against A2780 human ovarian cancer cells (IC₅₀ = 0.40 μM). Complex [¹⁸⁷Os]-1 was analysed by high-resoluti

SUBMITTER: Needham RJ 

PROVIDER: S-EPMC8477448 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature