Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta.

ABSTRACT:

Background

Amyloid-β (Aβ) immunotherapy is a promising therapeutic strategy in the fight against Alzheimer's disease (AD). A number of monoclonal antibodies have entered clinical trials for AD. Some of them have failed due to the lack of efficacy or side-effects, two antibodies are currently in phase 3, and one has been approved by FDA. The soluble intermediate aggregated species of Aβ, termed oligomers and protofibrils, are believed to be key pathogenic forms, responsible for synaptic and neuronal degeneration in AD. Therefore, antibodies that can strongly and selectively bind to these soluble intermediate aggregates are of great diagnostic and therapeutic interest.

Methods

We designed and recombinantly produced a hexavalent antibody based on mAb158, an Aβ protofibril-selec

SUBMITTER: Rofo F 

PROVIDER: S-EPMC8477473 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature