Association of deranged cerebrovascular reactivity with brain injury following cardiac arrest: a post-hoc analysis of the COMACARE trial.

ABSTRACT:

Background

Impaired cerebrovascular reactivity (CVR) is one feature of post cardiac arrest encephalopathy. We studied the incidence and features of CVR by near infrared spectroscopy (NIRS) and associations with outcome and biomarkers of brain injury.

Methods

A post-hoc analysis of 120 comatose OHCA patients continuously monitored with NIRS and randomised to low- or high-normal oxygen, carbon dioxide and mean arterial blood pressure (MAP) targets for 48 h. The tissue oximetry index (TO_x) generated by the moving correlation coefficient between cerebral tissue oxygenation measured by NIRS and MAP was used as a dynamic index of CVR with TO_x > 0 indicating impaired reactivity and TO_x > 0.3 used to delineate the lower and upper MAP bounds for disru

SUBMITTER: Laurikkala J 

PROVIDER: S-EPMC8477475 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature