Spatial variation in gene expression of Tasmanian devil facial tumors despite minimal host transcriptomic response to infection.

ABSTRACT:

Background

Transmissible cancers lie at the intersection of oncology and infectious disease, two traditionally divergent fields for which gene expression studies are particularly useful for identifying the molecular basis of phenotypic variation. In oncology, transcriptomics studies, which characterize the expression of thousands of genes, have identified processes leading to heterogeneity in cancer phenotypes and individual prognoses. More generally, transcriptomics studies of infectious diseases characterize interactions between host, pathogen, and environment to better predict population-level outcomes. Tasmanian devils have been impacted dramatically by a transmissible cancer (devil facial tumor disease; DFTD) that has led to widespread population declines. Despite initial pred

SUBMITTER: Kozakiewicz CP 

PROVIDER: S-EPMC8477496 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature