Single-cell RNA sequencing reveals markers of disease progression in primary cutaneous T-cell lymphoma.

ABSTRACT:

Background

In early-stage mycosis fungoides (MF), the most common primary cutaneous T-cell lymphoma, limited skin involvement with patches and plaques is associated with a favorable prognosis. Nevertheless, approximately 20-30% of cases progress to tumors or erythroderma, resulting in poor outcome. At present, factors contributing to this switch from indolent to aggressive disease are only insufficiently understood.

Methods

In patients with advanced-stage MF, we compared patches with longstanding history to newly developed plaques and tumors by using single-cell RNA sequencing, and compared results with early-stage MF as well as nonlesional MF and healthy control skin.

Results

Despite considerable inter-individual variability, lesion progression was uniformly associat

SUBMITTER: Rindler K 

PROVIDER: S-EPMC8477535 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature