Antiviral drugs for coronavirus disease 2019 (COVID-19): a systematic review with network meta-analysis.

ABSTRACT:

Background

To better inform clinical practice, we summarized the findings from randomized controlled trials (RCTs) of antivirals for COVID-19.

Methods

We systematically searched for literature up to September 2020, and included English-language publications of RCTs among hospitalized COVID-19 patients. We conducted network meta-analysis combining results of both the direct and indirect comparisons of interventions. The efficacy outcomes were clinical progression, all-cause mortality, and viral clearance, and safety outcomes were diarrhea, nausea, and vomiting. We generated treatment rankings (best to worst) and summarized rank probabilities using rankogram.

Results

We included 15 RCTs (14,418 patients) from 7,237 retrieved citations. There was no evidence for efficacy

SUBMITTER: Okoli GN 

PROVIDER: S-EPMC8477589 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature