Proprotein Convertase Subtilisin/Kexin Type 9 Loss-of-Function Is Detrimental to the Juvenile Host With Septic Shock.

ABSTRACT:

Objectives

Proprotein convertase subtilisin/kexin type 9 is a central regulator of lipid metabolism and has been implicated in regulating the host response to sepsis. Proprotein convertase subtilisin/kexin type 9 loss-of-function is associated with improved sepsis outcomes in the adult host through increased hepatic bacterial clearance. Thus, there is interest in leveraging proprotein convertase subtilisin/kexin type 9 inhibitors as a therapeutic strategy in adults with sepsis. We sought to validate this association in children with septic shock and in a juvenile murine model of sepsis.

Design

Prospectively enrolled cohort of children with septic shock; experimental mice.

Setting

Seventeen participating institutions; research laboratory.

Patients and subjects

F

SUBMITTER: Atreya MR 

PROVIDER: S-EPMC8477606 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature