An Investigation into the Temporal Reproducibility of Tryptophan Metabolite Networks Among Healthy Adolescents.

ABSTRACT: Tryptophan and its bioactive metabolites are associated with health conditions such as systemic inflammation, cardiometabolic diseases, and neurodegenerative disorders. There are dynamic interactions among metabolites of tryptophan. The interactions between metabolites, particularly those that are strong and temporally reproducible could be of pathophysiological relevance. Using a targeted metabolomics approach, the concentration levels of tryptophan and 18 of its metabolites across multiple pathways was quantified in 24-hours urine samples at 2 time-points, age 17 years (baseline) and 18 years (follow-up) from 132 (52% female) apparently healthy adolescent participants of the DOrtmund Nutritional and Anthropometric Longitudinally Designed (DONALD) Study. In sex-specific analyses, we appli

SUBMITTER: Oluwagbemigun K 

PROVIDER: S-EPMC8477685 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature