Association of Heart Failure With Outcomes Among Patients With Peripheral Artery Disease: Insights From EUCLID.

ABSTRACT: Background Peripheral artery disease (PAD) and heart failure (HF) are each independently associated with poor outcomes. Risk factors associated with new-onset HF in patients with primary PAD are unknown. Furthermore, how the presence of HF is associated with outcomes in patients with PAD is unknown. Methods and Results This analysis examined risk relationships of HF on outcomes in patients with symptomatic PAD randomized to ticagrelor or clopidogrel as part of the EUCLID (Examining Use of Ticagrelor in Peripheral Arterial Disease) trial. Patients were stratified based on presence of HF at enrollment. Cox models were used to determine the association of HF with outcomes. A separate Cox model was used to identify risk factors associated with development of HF during follow-up. Patients with

SUBMITTER: Samsky MD 

PROVIDER: S-EPMC8477881 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature