Deciphering of Candida parapsilosis induced immune response in Drosophila melanogaster.

ABSTRACT: Candida infections are the most prevalent cause of serious human mycoses and are the third most common pathogens isolated from bloodstream infections in hospitalized patients. C. parapsilosis is a member of the non-albicans spp., which have a predilection for causing life-threatening disease in neonates and hospitalized pediatric patients. In this study, we utilized a Drosophila melanogaster infection model to analyze the immunological responses to C. parapsilosis. Our results demonstrate that the Toll pathway in Drosophila controls C. parapsilosis proliferation as the Toll signaling mutant MyD88^-/- flies are highly susceptible to C. parapsilosis. We also confirmed that the MyD88^-/-<

SUBMITTER: Csonka K 

PROVIDER: S-EPMC8477938 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature