Evolutionary genetics and acclimatization in nephrology.

ABSTRACT: Evolutionary processes, including mutation, migration and natural selection, have influenced the prevalence and distribution of various disorders in humans. However, despite a few well-known examples, such as the APOL1 variants - which have undergone positive genetic selection for their ability to confer resistance to Trypanosoma brucei infection but confer a higher risk of chronic kidney disease - little is known about the effects of evolutionary processes that have shaped genetic variation on kidney disease. An understanding of basic concepts in evolutionary genetics provides an opportunity to consider how findings from ancient and archaic genomes could inform our knowledge of evolution and provide insights into how population migration and genetic admixture have shaped the current distr

SUBMITTER: Adeyemo AA 

PROVIDER: S-EPMC8478000 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature