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Selective symmetrical necrotizing encephalopathy secondary to primary mitochondrial disorder in a cat.

ABSTRACT: A 2-year-old female cat was referred for progressive neurological signs indicative of involvement of the prosencephalon, cerebellum, and brainstem. Magnetic resonance imaging identified multifocal, bilateral, symmetrical lesions with strong contrast enhancement, affecting multiple areas of the brain. Neuropathology at necropsy showed demyelination, necrotic lesions, spongiosis, and neuropil edema with reactive astrogliosis and neovascularization. Ultrastructural study indicated mitochondrial polymorphism. Genetic investigations outlined 2 polymorphisms within the tRNA-Leu^(UUR) gene of mitochondrial DNA. Imaging and neuropathological findings were consistent with selective symmetrical necrotizing encephalopathy, for which genetic investigations support mitochondrial pathogenesis.

SUBMITTER: Dell'Era E

PROVIDER: S-EPMC8478069 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Selective symmetrical necrotizing encephalopathy secondary to primary mitochondrial disorder in a cat.

Dell'Era Elena E Polidori Margherita M Bernardini Marco M Capomaccio Stefano S Cappelli Katia K Balducci Federica F Mandara Maria T MT

Journal of veterinary internal medicine 20210722 5

A 2-year-old female cat was referred for progressive neurological signs indicative of involvement of the prosencephalon, cerebellum, and brainstem. Magnetic resonance imaging identified multifocal, bilateral, symmetrical lesions with strong contrast enhancement, affecting multiple areas of the brain. Neuropathology at necropsy showed demyelination, necrotic lesions, spongiosis, and neuropil edema with reactive astrogliosis and neovascularization. Ultrastructural study indicated mitochondrial pol ...[more]

PMID: 34291836

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