Effects of desmopressin acetate administration in healthy dogs receiving prednisolone.

ABSTRACT:

Background

Glucocorticoids are used for a variety of purposes in veterinary medicine but often are associated with clinically important adverse effects. Polyuria and polydipsia are the most frustrating adverse effects noted by owners.

Objective

To determine whether administration of desmopressin ameliorates polyuria and polydipsia associated with prednisolone administration.

Animals

Seven healthy adult Walker Hounds.

Methods

Prospective hypothesis testing study. Daily water intake and urine specific gravity (USG) were measured in dogs under 4 separate sequential conditions: no medications (C), prednisolone only (P), prednisolone and desmopressin (PD), and prednisolone after discontinuation of desmopressin (PAD).

Results

When compared to baseline, 6 of 7

SUBMITTER: Galati P 

PROVIDER: S-EPMC8478070 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature