Time-delay structure predicts clinical scores for patients with disorders of consciousness using resting-state fMRI.

ABSTRACT:

Background

The detection of intrinsic brain activity (iBA) could assist clinical assessment for disorder of consciousness (DOC) patients. Previous studies have revealed the altered iBA in thalamocortical, frontoparietal, and default mode network in DOC patients using functional connectivity (FC) analysis. However, due to the assumption of synchronized iBA in FC, these studied may be inadequate for understanding the effect of severe brain injury on the temporal organization of iBA and the relationship between temporal organization and clinical feature in DOC patients. Recently, the time delay estimation (TDE) and probabilistic flow estimation (PFE) were proposed to analyze temporal organization, which could provide propagation structure and propagation probability at whole-brain lev

SUBMITTER: Cao B 

PROVIDER: S-EPMC8478145 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature