Gram-negative neonatal sepsis in low- and lower-middle-income countries and WHO empirical antibiotic recommendations: A systematic review and meta-analysis.

ABSTRACT:

Background

Neonatal sepsis is a significant global health issue associated with marked regional disparities in mortality. Antimicrobial resistance (AMR) is a growing concern in Gram-negative organisms, which increasingly predominate in neonatal sepsis, and existing WHO empirical antibiotic recommendations may no longer be appropriate. Previous systematic reviews have been limited to specific low- and middle-income countries. We therefore completed a systematic review and meta-analysis of available data from all low- and lower-middle-income countries (LLMICs) since 2010, with a focus on regional differences in Gram-negative infections and AMR.

Methods and findings

All studies published from 1 January 2010 to 21 April 2021 about microbiologically confirmed bloodstream infectio

SUBMITTER: Wen SCH 

PROVIDER: S-EPMC8478175 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature