Conventional measures of intrinsic excitability are poor estimators of neuronal activity under realistic synaptic inputs.

ABSTRACT: Activity-dependent regulation of intrinsic excitability has been shown to greatly contribute to the overall plasticity of neuronal circuits. Such neuroadaptations are commonly investigated in patch clamp experiments using current step stimulation and the resulting input-output functions are analyzed to quantify alterations in intrinsic excitability. However, it is rarely addressed, how such changes translate to the function of neurons when they operate under natural synaptic inputs. Still, it is reasonable to expect that a strong correlation and near proportional relationship exist between static firing responses and those evoked by synaptic drive. We challenge this view by performing a high-yield electrophysiological analysis of cultured mouse hippocampal neurons using both standard proto

SUBMITTER: Szabo A 

PROVIDER: S-EPMC8478185 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature