A Cutibacterium acnes antibiotic modulates human skin microbiota composition in hair follicles.

ABSTRACT: The composition of the skin microbiota varies widely among individuals when sampled at the same body site. A key question is which molecular factors determine strain-level variability within sub-ecosystems of the skin microbiota. Here, we used a genomics-guided approach to identify an antibacterial biosynthetic gene cluster in Cutibacterium acnes (formerly Propionibacterium acnes), a human skin commensal bacterium that is widely distributed across individuals and skin sites. Experimental characterization of this biosynthetic gene cluster resulted in identification of a new thiopeptide antibiotic, cutimycin. Analysis of individual human skin hair follicles revealed that cutimycin contributed to the ecology of the skin hair follicle microbiota and helped to reduce colonization

SUBMITTER: Claesen J 

PROVIDER: S-EPMC8478231 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature