Maternal hypertensive disorder of pregnancy and offspring early-onset cardiovascular disease in childhood, adolescence, and young adulthood: A national population-based cohort study.

ABSTRACT:

Background

The prevalence of cardiovascular disease (CVD) has been increasing in children, adolescents, and young adults in recent decades. Exposure to adverse intrauterine environment in fetal life may contribute to the elevated risk of early-onset CVD. Many studies have shown that maternal hypertensive disorders of pregnancy (HDP) are associated with increased risks of congenital heart disease, high blood pressure, increased BMI, and systemic vascular dysfunction in offspring. However, empirical evidence on the association between prenatal exposure to maternal HDP and early-onset CVD in childhood and adolescence remains limited.

Methods and findings

We conducted a population-based cohort study using Danish national health registers, including 2,491,340 individuals born in

SUBMITTER: Huang C 

PROVIDER: S-EPMC8478255 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature