Association between delay in intensive care unit admission and the host response in patients with community-acquired pneumonia.

ABSTRACT:

Background

A delay in admission to the intensive care unit (ICU) of patients with community-acquired pneumonia (CAP) has been associated with an increased mortality. Decisions regarding interventions and eligibility for immune modulatory therapy are often made at the time of admission to the ICU. The primary aim of this study was to compare the host immune response measured upon ICU admission in CAP patients admitted immediately from the emergency department (direct ICU admission) with those who were transferred within 72 h after admission to the general ward (delayed ICU admission).

Methods

Sixteen host response biomarkers providing insight in pathophysiological mechanisms implicated in sepsis and blood leukocyte transcriptomes were analysed in patients with CAP upon ICU ad

SUBMITTER: Pereverzeva L 

PROVIDER: S-EPMC8478267 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature