Behavior of Proteins under Pressure from Experimental Pressure-Dependent Structures.

ABSTRACT: Structure-based models are coarse-grained representations of the interactions responsible for the protein folding process. In their simplest form, they use only the native contact map of a given protein to predict the main features of its folding process by computer simulation. Given their limitations, these models are frequently complemented with sequence-dependent contributions or additional information. Specifically, to analyze the effect of pressure on the folding/unfolding transition, special forms of these interaction potentials are employed, which may a priori determine the outcome of the simulations. In this work, we have tried to keep the original simplicity of structure-based models. Therefore, we have used folded structures that have been experimentally determined at different p

SUBMITTER: Fernandez Del Rio B 

PROVIDER: S-EPMC8478274 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature