Influential Factors and Efficacy Analysis of Tacrolimus Concentration After Allogeneic Hematopoietic Stem Cell Transplantation in Children with β-Thalassemia Major.

ABSTRACT:

Purpose

To analyze factors influencing tacrolimus (TAC) trough concentration (C₀) in β-thalassemia major (β-TM) pediatric patients after allogeneic hematopoietic stem cell transplantation (Allo-HSCT) and to investigate the effects of genotype polymorphism and drug-drug interactions on TAC trough concentration in children with β-TM. Furthermore, to analyze the correlation between TAC C₀ and efficacy and adverse reactions.

Patients and methods

Prospectively collection of demographic information and details of combined treatment of patients with β-TM receiving HSCT, and genotypes of CYP3A4, CYP3A5, and ABCB1 (rs1045642, rs1128503, rs2032582) were obtained for each patient. Univariate analysis and multiple linear regression analysis were used to investigate

SUBMITTER: Li C 

PROVIDER: S-EPMC8478485 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature