Identification of a Four-lncRNA Prognostic Signature for Colon Cancer Based on Genome Instability.

ABSTRACT: LncRNAs (long noncoding RNAs) are closely associated with genome instability. However, the identification of lncRNAs related to the genome instability and their relationship with the prognosis and clinical signature of cancer remains to be explored. In this paper, we analyzed differential lncRNA expression based on the somatic mutation profiles of colon cancer patients from TCGA database and finally identified 153 lncRNAs that are associated with genome instability in colon cancer. Taking four lncRNAs from these 153, we established a genome-instability-related prognostic signature (GIRlncPSig). By applying the GIRlncPSig, we calculated a risk score for each patient, and using their risk scores, we divided them into low- and high-risk groups. We found that the prognosis between the two risk

SUBMITTER: Yun D 

PROVIDER: S-EPMC8478558 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature