The Role of Inflammasome Activation in Early HIV Infection.
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ABSTRACT:
SUBMITTER: Ekabe CJ
PROVIDER: S-EPMC8478595 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
The Role of Inflammasome Activation in Early HIV Infection.
Ekabe Cyril Jabea CJ Clinton Njinju Asaba NA Kehbila Jules J Franck Ngangom Chouamo NC
Journal of immunology research 20210920
The inflammasome pathway is an important arm of the innate immune system that provides antiviral immunity against many viruses. The main pathways involved in virus infections include the NLRP3, IFI16, and AIM2 pathways. However, a succinct understanding of its role in HIV is not yet well elucidated. In this review, we showed that NLRP3 inflammasome activation plays a vital role in inhibiting HIV entry into target cells via the purinergic pathway; IFI16 detects intracellular HIV ssDNA, triggers i ...[more]
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