Development and validation of a comorbidity index for predicting survival outcomes after allogeneic stem cell transplantation in adult patients with acute leukemia: a Korean nationwide cohort study.

ABSTRACT:

Background

Allogeneic hematopoietic stem cell transplantation (alloSCT) is a potentially curative treatment option for acute leukemia. We aimed to identify the comorbidity factors affecting survival outcomes after alloSCT and develop a new comorbidity index tool for predicting overall survival (OS).

Methods

A Korean nationwide cohort of 3,809 adults with acute leukemia treated with alloSCT between January 2002 and December 2018 was analyzed as the development cohort. A retrospective cohort comprising 313 consecutive adults with acute leukemia who underwent alloSCT between January 2019 and April 2020 was analyzed as the validation cohort.

Results

In the development cohort, advanced age, male sex, and comorbidities such as previous non-hematologic malignancy, hypertensi

SUBMITTER: Park SS 

PROVIDER: S-EPMC8478627 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature