Comparative venous thromboembolic safety of oral and transdermal postmenopausal hormone therapies among women Veterans.

ABSTRACT:

Objective

Hormone therapy (HT) is used by menopausal women to treat vasomotor symptoms. Venous thromboembolism (VTE) is an important risk of HT use, and more knowledge on the comparative safety of different estrogenic compounds is useful for women who use HT for these symptoms. The objective was to compare the risk of VTE among users of oral conjugated equine estrogen (CEE), oral estradiol (E2), and transdermal E2, in a cohort of women veterans.

Methods

This retrospective cohort study included all women veterans aged 40 to 89 years, using CEE or E2, without prior VTE, between 2003 and 2011. All incident VTE events were adjudicated. Time-to-event analyses using a time-varying HT exposure evaluated the relative VTE risk between estrogen subtypes, with adjustment for age, race,

SUBMITTER: Blondon M 

PROVIDER: S-EPMC8478712 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature