Neuronal CD200 Signaling Is Protective in the Acute Phase of Ischemic Stroke.

ABSTRACT:

Background and purpose

CD200 (cluster of differentiation 200), a highly glycosylated protein primarily expressed on neurons in the central nervous system, binds with its receptor CD200R to form an endogenous inhibitory signal against immune responses. However, little is known about the effect of neuronal CD200 signaling in cerebral ischemia. The aim of this study was to investigate how neuronal CD200 signaling impacts poststroke inflammation and the ischemic injury.

Methods

CD200 tma1lf/fl:Thy1CreER mice were treated with tamoxifen to induce conditional gene knockout (ICKO) of neuronal CD200. The mice were subjected to a 60-minute transient middle cerebral artery occlusion. Stroke outcomes, apoptotic cell death, immune cell infiltration, microglia activation, and other infla

SUBMITTER: Al Mamun A 

PROVIDER: S-EPMC8478808 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature