Metabolomic signatures of the short-term exposure to air pollution and temperature.

ABSTRACT:

Background

Short-term exposures to air pollution and temperature have been reported to be associated with inflammation and oxidative stress. However, mechanistic understanding of the affected metabolic pathways is still lacking and literature on the short-term exposure of air-pollution on the metabolome is limited.

Objectives

We aimed to determine changes in the plasma metabolome and associated metabolic pathways related to short-term exposure to outdoor air pollution and temperature.

Methods

We performed mass-spectrometry based untargeted metabolomic profiling of plasma samples from a large and well-characterized cohort of men (Normative Aging Study) to identify metabolic pathways associated with short-term exposure to PM_2.5, NO₂, O₃,

SUBMITTER: Nassan FL 

PROVIDER: S-EPMC8478827 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature