Individual prediction of nonadherence to oral mercaptopurine in children with acute lymphoblastic leukemia: Results from COG AALL03N1.

ABSTRACT:

Background

Poor mercaptopurine (6MP) adherence (mean adherence rate < 90%) increases the relapse risk among children with acute lymphoblastic leukemia (ALL). 6MP adherence remains difficult to measure in real time. Easily measured patient-level factors could identify patients at risk for poor adherence.

Methods

The authors measured 6MP adherence via electronic monitoring for 6 months per patient. Using data from month 3, they created a risk prediction model for 6MP nonadherence in 407 children with ALL (mean age, 7.7 ± 4.4 years); they used receiver operating characteristic analyses in the training set (n = 250) and replicated this in the test set (n = 157).

Results

Age, race/ethnicity, 6MP dose intensity, absolute neutrophil count, 6MP ingestion patterns, and househo

SUBMITTER: Hoppmann AL 

PROVIDER: S-EPMC8478829 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature