Association of plasma ceramides with prevalent and incident type 2 diabetes mellitus in middle and older aged adults.

ABSTRACT:

Aims

The role of ceramides in the pathogenesis of type 2 diabetes mellitus (T2DM) is incompletely characterized. Given that ceramides represent therapeutic targets to disrupt the euglycemia-T2DM transition, we aimed to characterize their association with prevalent and incident T2DM in a novel cohort.

Methods

We examined the cross-sectional and longitudinal association of baseline ceramides with prevalent and incident T2DM among 1423 adults (47% women; median (range) baseline age 72 (51-95) years) in the Mayo Clinic Study of Aging cohort. We examined the associations of ceramides with prevalent T2DM (adjusted odds ratio [95% confidence interval]) at baseline and incident T2DM (adjusted hazard ratio [95% confidence interval]) during median follow-up of 6.2 years, after adjusti

SUBMITTER: Dugani SB 

PROVIDER: S-EPMC8478833 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature