Air Pollution and Autism Spectrum Disorder in Israel: A Negative Control Analysis.

ABSTRACT:

Background

Residual confounding is a major concern for causal inference in observational studies on air pollution-autism spectrum disorder (ASD) associations. This study is aimed at assessing confounding in these associations using negative control exposures.

Methods

This nested case-control study included all children diagnosed with ASD (detected through 31 December 2016) born during 2007-2012 in Israel and residing in the study area (N = 3,843), and matched controls of the same age (N = 38,430). We assigned individual house-level exposure estimates for each child. We estimated associations using logistic regression models, mutually adjusted for all relevant exposure periods (prepregnancy, pregnancy, and postnatal). We assessed residual confounding using postoutcome negativ

SUBMITTER: Magen-Molho H 

PROVIDER: S-EPMC8478838 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature