A transcriptome-wide association study to detect novel genes for volumetric bone mineral density.

ABSTRACT: Transcriptome-wide association studies (TWAS) systematically investigate the association of genetically predicted gene expression with disease risk, providing an effective approach to identify novel susceptibility genes. Osteoporosis is the most common metabolic bone disease, associated with reduced bone mineral density (BMD) and increased risk of osteoporotic fractures, whereas genetic factors explain approximately 70% of the variance in phenotypes associated with bone. BMD is commonly assessed using dual-energy X-ray absorptiometry (DXA) to obtain measurements (g/cm²) of areal BMD. However, quantitative computed tomography (QCT) measured 3D volumetric BMD (vBMD) (g/cm³) has important advantages compared with DXA since it can evaluate cortical and trabecular microstr

SUBMITTER: Liu A 

PROVIDER: S-EPMC8478845 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature